Cellular polarity and viral infection
In the Boulant Lab, we are investigating how cellular polarity is achieved and regulated in intestinal epithelium and how it participates in the maintenance of barrier functions and in the control of viral infection.
Our main research questions are:
We use a multidisciplinary approach to investigate fundamental aspects of cellular biology , immunology and virology.
We use epithelium and organoids model systems to recapitulate the complexity of the intestinal tract.
How enteric viral pathogens infect the epithelial cells lining the surface of our gastro-intestinal track.
How clathrin-mediated endocytosis and trafficking are regulated in polarized cells.
How cellular polarity participates in the maintenance of epithelium immune homeostasis.