Virus entry and replication
Reovirus replication compartments
Reovirus T3D viral factories and microtubules
Multilayer organization of reovirus
Reovirus viral factories and actin
TEM of reovirus viral factories
Reovirus T1L viral factories and microtubules
RNA viruses replicate in the cytosol of the host cell. In order to avoid recognition by the host, replication takes place in cellular membrane-derived replication compartments. Reovirus has developed a different strategy by hijacking the cellular microtubule network to organize and coordinate its replication and assembly. We are investigating the molecular basis of this novel repliaction strategy.