Virus entry and replication
Reovirus replication compartments
 Reovirus T3D viral factories and microtubules |
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 Multilayer organization of reovirus |
 Reovirus viral factories and actin |
 TEM of reovirus viral factories |
 Reovirus T1L viral factories and microtubules |
RNA viruses replicate in the cytosol of the host cell. In order to avoid recognition by the host, replication takes place in cellular membrane-derived replication compartments. Reovirus has developed a different strategy by hijacking the cellular microtubule network to organize and coordinate its replication and assembly. We are investigating the molecular basis of this novel repliaction strategy.