Virus entry and replication

Reovirus replication compartments

Reovirus T3D viral factories and microtubules

Multilayer organization of reovirus

Reovirus viral factories and actin

TEM of reovirus viral factories

Reovirus T1L viral factories and microtubules

RNA viruses replicate in the cytosol of the host cell. In order to avoid recognition by the host, replication takes place in cellular membrane-derived replication compartments. Reovirus has developed a different strategy by hijacking the cellular microtubule network to organize and coordinate its replication and assembly. We are investigating the molecular basis of this novel repliaction strategy.